Cheap flights from Manchester to South Africa The three major centres of South Africa are Johannesburg, Cape Town and Durban (in that order of size). Flights from Manchester to Johannesburg and Manchester to Cape Town have at least one stop, whilst flights from Manchester to Durban have at least 2 stops.
If your plans are to fly to Durban, first fly from Manchester to Johannesburg (or Manchester to Cape Town), and then catch a local flight from Johannesburg to Durban (or Cape Town to Durban). The links below contain a full list of airlines operating flights on each route and links to their online flight reservation systems.
There are more airlines operating flights from London to South Africa, than from Manchester, meaning there is a good chance that flights from London to South Africa are cheaper than flights from Manchester to South Africa. If you can easily travel from Manchester to London, it may be worthwhile checking the prices of airlines operating flights from London to South Africa.